琺瑯質由 97wt.%納米羥基磷灰石、3wt.%有機材料和水組成。在牙本質中,納米羥基磷灰石佔 70wt.%。

由於納米羥基磷灰石是琺瑯質的主要成分,它透過模擬天然牙本質羥基磷灰石封閉琺瑯質表面的小孔進行表面修復,賦予亮白色外觀並消除光的漫反射性。 

加入到牙膏和漱口液中是絕佳的選擇!


nanoXIM • CarePaste 有效滲透和封閉暴露的牙本質小管

 

可以有效滲透和封閉暴露的牙本質小管。

密封了牙本質小管並防止神經暴露於外部刺激,從而減少牙齒過敏。

與牙本質磷灰石和琺瑯質結合,形成新的磷灰石層,使琺瑯質再礦化平滑並保護牙齒表面免受食物和飲料中的酸造成的損害。

oral content01


應用

 

      • 減少和預防牙齒過敏
      • 增強琺瑯質再礦化過程。
      • 有助於使牙齒表面光滑,具有自然的亮白效果。

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  1. CarePaste_膏狀
  2. CarePowder_粉末
  3. 白皮書
  4. 文獻

nanoXIM • CarePaste
INCI name: Hydroxyapatite (nano)
IUPAC name:  Pentacalcium hydroxide triphosphate

 

nanoXIM • CarePaste 是一種合成奈米羥基磷灰石水基懸浮成分。推薦添加到口腔護理產品中,例如牙膏、漱口水、凝膠和其他專業牙科產品。
其中包含的羥基磷灰石納米顆粒形成與牙釉質羥基磷灰石相同的完美排列的納米晶體結構,使牙釉質再礦化。
由於羥基磷灰石顆粒的納米尺寸,nanoXIM•CarePaste 能夠密封牙本質小管並防止神經暴露於外部刺激,從而降低牙齒過敏。

  • 羥基磷灰石納米顆粒(< 50 nm)
  • 高表面積
  • 低相對牙本質磨蝕性 (RDA < 10)
  • 自防腐產品(無添加 對羥基苯甲酸酯防腐劑Parabens)
  • 保質期3年
  • 透過羥基磷灰石顆粒的奈米尺寸有效封閉牙本質小管,防止神經暴露於外部刺激、減少牙齒過敏
  • 與牙齒表面的高親和力,促進琺瑯質再礦化
  • 平滑和保護牙齒表面免受食物和飲料中的酸造成的損害

 

 

nanoXIMCarePaste

 

nanoXIMCarePaste2

 

nanoXIMCarePaste3

 CarePaste  高解析   電子晶體學圖像 

 

 技術資料

 Download Technical Data Sheet

 

 

 

   Benefits 好處

通過有效封閉牙本質小管降低牙齒過敏

由於與牙齒表面結合的高親和力,促進牙釉質再礦化

平滑並保護牙齒表面免受食物和飲料中的酸造成的損害

   Features 特色

羥基磷灰石納米顆粒(< 50 nm)

高表面積

低相對牙本質磨蝕性(RDA < 10)

合成材料

自防腐產品(無添加對羥基苯甲酸酯防腐劑Parabens)

保質期3年

 

 

 

 

Effectiveness of nanoXIM•CarePaste on dentin tubule occlusion and enamel remineralization
nanoXIM•CarePaste對牙本質小管閉塞和牙釉質再礦化的有效性

 pdf icon下載白皮書

 

Clinical efficacy of a dentifrice containing nanoXIM•CarePaste
奈米羥基磷灰石牙膏與氟化物牙膏在降低牙齒過敏方面的對比

  pdf icon下載白皮書

 

Nano-hydroxyapatite toothpaste vs Fluoride toothpaste in reducing dental hypersensitivity
奈米羥基磷灰石牙膏與氟化物牙膏在降低牙齒過敏方面的對比

 pdf icon下載白皮書

 

 

nanoXIM•CarePowder白色粉末狀,由羥基磷灰石的微米級聚集體組成。

推薦用於不能摻入水性成分的口腔護理產品,例如牙粉、壓縮牙片、牙膏和一些特定的美白產品。

  • 適用於不能加入水性成分的最終產品,針對過敏、牙釉質再礦化和齲齒預防。磷酸鈣羥基磷灰石
  • 適用於美容產品
  • 霧化細粉
  • 高表面積

 

nanoXIMCarePowder

 

nanoXIMCarePowder02

 

nanoXIMCarePaste3

 CarePower  高解析   電子晶體學圖像 

 

nanoXIM•CarePowder is a white powder consisting of micrometric aggregates of hydroxyapatite.

This powder is recommended for oral care products that cannot incorporate aqueous ingredients, such as tooth powders, compressed tooth tablets, dental varnishes and some specific whitening products.

 

   Benefits

Suitable for end products that cannot incorporate aqueous ingredients as dental varnishes and some specific whitening products, targeting hypersensitivity, enamel remineralization and caries prevention.

   Features

Calcium phosphate hydroxyapatite

Suitable for cosmetics

Atomized fine powder

High surface area

Synthetic material

 

  • Effectiveness of nanoXIM•CarePaste on dentin tubule occlusion and enamel remineralization 
    nanoXIM•CarePaste對牙本質小管閉塞和牙釉質再礦化的有效性

牙齒過敏是由持續的牙齒侵蝕引起的,其特點是短暫而劇烈的疼痛,通常可以透過在牙膏中加入脫敏劑來治療。

nanoXIM•CarePaste用於牙膏配方時,可以有效填充牙本質小管減少牙齒過敏,以及能夠使琺瑯質表面再礦化來減少早期齲損

CarePasteWhitepaper

 pdf icon下載白皮書

 

 

 

  • Nano-hydroxyapatite toothpaste vs Fluoride toothpaste in reducing dental hypersensitivity
    奈米羥基磷灰石牙膏與氟化物牙膏在降低牙齒過敏方面的對比

該臨床試驗比較了含有 nanoXIM•CarePaste 的牙膏與其他兩種不含nanoXIM•CarePaste的牙膏在減少牙齒過敏方面的效果

分別在 75% 和 100% 的情況下,含有nanoXIM•CarePaste的牙膏比牙膏 1 和牙膏 2 表現更好。
nanoXIM•CarePaste是治療牙齒過敏症最有效的方法,
在治療 2週後立即為所有進行的測試提供了更快的疼痛緩解,在 3 個月後顯著減輕疼痛。

 

 pdf icon下載白皮書

 

 

 

  • Clinical efficacy of a dentifrice containing nanoXIM•CarePaste
    奈米羥基磷灰石牙膏與氟化物牙膏在降低牙齒過敏方面的對比

在臨床試驗中,使用觸覺和冷空氣刺激評估超敏反應,相比含有 nanoXIM•CarePaste 的牙膏、含有氟化物的牙膏在減少牙齒過敏上的功效。

這項研究表明,含有 nanoXIM•CarePaste 的牙膏能夠顯著降低牙齒在觸覺和冷空氣刺激上的過敏,而安慰劑和含氟牙膏是無法做到的。

 

 pdf icon下載白皮書

 

Biomimetic tooth-whitening effect of hydroxyapatite-containing mouthrinses after long-term simulated oral rinsing

R. Shang, K.-H. Kunzelmann, “Biomimetic tooth-whitening effect of hydroxyapatite-containing mouthrinses after long-term simulated oral rinsing”, American Journal of Dentistry 34(6), p. 307 (2021).

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A Radical-Free Approach to Teeth Whitening
M. Pascolutti, D. de Oliveira, “A Radical-Free Approach to Teeth Whitening”, Dentistry Journal; 9(12), p. 148 (2021).

Physical and Chemical Characterizations of Novel Bioactive Caries Detecting Solution

G. Shashirekha, K.K. Sushant, N. Binita, J. Amit, M. Neeta, “Physical and Chemical Characterizations of Novel Bioactive Caries Detecting Solution”, Dental Hypotheses, 12(1), p. 8 (2021).

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Clinical efficacy of single application of plain nano hydroxyapatite paste in reducing dentine hypersensitivity – A randomized clinical trial

D.N. Alharith, M. Al-Omari, R. Almnea, R. Basri, A.H. Alshehri, A.A. Al-Nufiee, “Clinical efficacy of single application of plain nano hydroxyapatite paste in reducing dentine hypersensitivity – A randomized clinical trial”, Saudi Endodontic Journal, 11 (1), p. 24 (2021).

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Effects of Experimental Nano-Hydroxyapatite Pastes on Remineralization of Early Demineralized Enamel

A. Vacharangkura, S. Kunawarote, “Effects of Experimental Nano-Hydroxyapatite Pastes on Remineralization of Early Demineralized Enamel”, Proceedings of RSU International Research Conference 2021, p. 109 (2021).

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Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study

R.D. Geeta, S. Vallabhaneni, K. Fatima, “Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study”, Journal of Conservative Dentistry, 23(3), p. 275 (2020).

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In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding

M.N. Luong, L. Huang, D.C.N. Chan, A. Sadr, “In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding”, Journal of Functional Biomaterials, 11(2), p. 38 (2020).

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Novel bioactive caries-detecting dye solution: Cytotoxicity, antimicrobial activity, scanning electron microscope, and stereomicroscopic analysis in diagnosis of dental caries

G. Shashirekha, A. Jena, N. Mohanty, S.K. Kamilla, “Novel bioactive caries-detecting dye solution: Cytotoxicity, antimicrobial activity, scanning electron microscope, and stereomicroscopic analysis in diagnosis of dental caries”, Journal of Conservative Dentistry, 23 (1), p. 79 (2020)

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Enhanced toothpaste and kits

D. Debaun, “Enhanced toothpaste and kits”, WO2021046047A1 patent (2020).

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Nanohydroxyapatite (n-HAp) as a pickering stabilizer in oil-in-water (O/W) emulsions: a stability study

A. Ribeiro, Y.A. Manrique, I.C.F.R. Ferreira, M.F. Barreiro, J.C.B. Lopes, M.M. Dias, “Nanohydroxyapatite (n-HAp) as a pickering stabilizer in oil-in-water (O/W) emulsions: a stability study”, Journal of Dispersion Science and Technology, DOI: 10.1080/01932691.2020.1845199 (2020).

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Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment

C.C. Coelho, L. Grenho, P. Gomes, P.A. Quadros and M.H. Fernandes, “Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment”, Scientific Reports 9, Article number: 11050 (2019).

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Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis

C.M. Alencar, B.L.F. Paula, M.I.G. Ortiz, M.B. Magno, C.M. Silva, L.C. Maia, “Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis”, Journal of Dentistry 82, p. 11 (2019).

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Comparative evaluation of neodymium-doped yttrium aluminum garnet laser with nanocrystalline hydroxyapatite dentifrices and herbal dentifrices in the treatment of dentinal hypersensitivity

R.K. Yadav, U.P. Verma, R. Tiwari, “Comparative evaluation of neodymium-doped yttrium aluminum garnet laser with nanocrystalline hydroxyapatite dentifrices and herbal dentifrices in the treatment of dentinal hypersensitivity”, Natl J Maxillofac Surg., 10(1), p.78 (2019).

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Comparison of efficacy of nanohydroxyapatite desensitizer, ND:YAG Laser and their combined effect in the treatment of dentin hypersensitivity: a clinical study

A. Arya, A. Arora, “Comparison of efficacy of nanohydroxyapatite desensitizer, ND:YAG Laser and their combined effect in the treatment of dentin hypersensitivity: a clinical study”, International Journal of Scientific Research, 8(9), p. 54 (2019).

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Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

P. Usai, V. Campanella, G. Sotgiu, G. Spano, R. Pinna, S. Eramo, L. Saderi, F. Garcia-Godoy, G. Derchi, G. Mastandrea, E. Milia, “Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation”, Nanomaterials, 9, 1748; doi:10.3390/nano9121748 (2019).

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A Comparative Evaluation of Three Different Remineralizing Agents on Aertificially created Surface Carious Lesion: An In Vitro study

T. Sowmiya, “A Comparative Evaluation of Three Different Remineralizing Agents on Aertificially created Surface Carious Lesion: An In Vitro study.”, MSc thesis, Vivekanandha Dental College for Women, Tiruchengode (2019).

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Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation 

J.M. Ramis, C.C. Coelho, A. Córdoba, P.A. Quadros, M. Monjo, “Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation”, Cosmetics 5(3), 53 (2018).

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Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, R. Pinna, P. Usai, U. Covani, “Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial”, Clinical Oral Investigations, 22(1), p. 313 (2018).

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Experimental mouth rinse with nano-HAp to be used at home for dental erosion treatment

F.S. Calazans, M.J. Anjos, R.S. Santos, R.P. Mendonça, T.M.J. Ferreira, G.R. Pereira, J.T. Assis, M.S. Miranda, “Experimental mouth rinse with nano-HAp to be used at home for dental erosion treatment”, J Clin Dent Res., 15(2), p.62 (2018).

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Comparative Evaluation of Surface Microhardness of Artificially Demineralized Human Enamel with Nano Hydroxyapatite, Calcium Phosphate, and Potassium Nitrate Remineralizing Agents: An In Vitro Study

P. Madhusudanan, P. SV, R. Pillai, N.O. Varghese, S. George, A. Antony, “Comparative Evaluation of Surface Microhardness of Artificially Demineralized Human Enamel with Nano Hydroxyapatite, Calcium Phosphate, and Potassium Nitrate Remineralizing Agents: An In Vitro Study”, Conservative Dentistry and Endodontic Journal, 3(2), p. 50 (2018).

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Evaluation of the remineralization potential of two non-fluoridated remineralizing pastes using scanning electron microscope with energy dispersive X-ray analysis: A randomized controlled in-vitro trial

V. Vijayasankari, “Evaluation of the remineralization potential of two non-fluoridated remineralizing pastes using scanning electron microscope with energy dispersive X-ray analysis: A randomized controlled in-vitro trial”, MSc Thesis of Dental Surgery, The Tamil Nadu Dr. M.G.R. Medical University (2018).

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Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis
 A. Jena, S. Kala, G. Shashirekha, “Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis”, Journal of Conservative Dentistry, 20(4), p. 269 (2017).

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Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules

P. Tempesti, G.S. Nicotera, M. Bonini, E. Fratini, P. Baglioni, “Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules”, Journal of Colloid and Interface Science doi: https://dx.doi.org/10.1016/j.jcis.2017.09.001 (2017).

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Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study

A. Singh, B. Shetty, C.M. Mahesh, V.P. Reddy, B.S. Chandrashekar, S. Mahendra, “Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study”, The Journal of Indian Orthodontic Society, 51(2), p. 92 (2017).

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Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth 

A. Ebadifar, M. Nomani, S.A. Fatemi, “Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth”, Journal of Dental Research, Dental Clinics, Dental Prospects, 11(1), p. 14. (2017).

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Comparative Evaluation of Effect of Nano-hydroxyapatite and 8% Arginine Containing Toothpastes in Managing Dentin Hypersensitivity: Double Blind Randomized Clinical Trial

S. Anand, F. Rejula, J.V.G. Sam, R. Christaline, M.G. Nair, S. Dinakaran, “Comparative Evaluation of Effect of Nano-hydroxyapatite and 8% Arginine Containing Toothpastes in Managing Dentin Hypersensitivity: Double Blind Randomized Clinical Trial”, Acta Medica (Hradec Králové), 60(3), p. 114 (2017).

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An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study

R. Kulal, I. Jayanti, S. Sambashivaiah, S. Bilchodmath, “An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study”, Journal of Clinical and Diagnostic Research 10(10), p. 51 (2016).

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Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants

S. B. Low, E. P. Allen, E. D. Kontogiorgos, “Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants”, The Open Dentistry Journal, 9, p. 92 (2015).

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Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos

M. Jiménez Ochoa, “Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos”, MSc Thesis Ortodoncia, Universidad San Francisco de Quito, Ecuador (2015).

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Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.

M. Vano, G. Derchi, A. Barone, A. Genovesi, U. Covani, “Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.”, International Journal of Dental Hygiene, 13(4), p. 301 (2015).

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Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study

A. Jena, G. Shashirekha, “Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study”, Journal of Conservative Dentistry, 18(5), p. 389 (2015).

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Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent

M. Amin, R. Mehta, S. Duseja, K. Desai, “Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent”, Advances in Human Biology 5(1), p. 34 (2015).

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Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial

N. M. Gopinath, J. John, N. Nagappan, S. Prabhu, E. S. Kumar, “Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial”, Journal of International Oral Health, 7(8), p. 118 (2015).

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Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, U. Covani, “Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial”, Quintessence International, 45(8), p. 703 (2014). 

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An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents

N. VJ, S. Thakur, “An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents”, Research and Reviews: Journal of Dental Sciences, 2(2), p. 113 (2014). 

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A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity

Pinojj, A. Shetty, D. Shetty, S. Shetty, “A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity - A Comparative Triple Blind Randomized Study”, Advances in Human Biology, 4(2) p. 57 (2014).

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Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial

P. Verma, U. Gupta, V. Dodwad, B. Kukreja, K. Arora, “Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial”, Journal of Dental Specialities, 1(2), p. 47 (2013).

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